Metformin decreases liver uptake of lactate increasing lactate blood levels which may increase the risk of lactic acidosis, especially in patients at risk. Hypoglycemia was reported in approximately 10% of cases, but no causal association with metformin hydrochloride has been established. Diaβeta is excreted as metabolites in the and urine, approximately 50% by each route. This dual excretory pathway is qualitatively different from that of other sulfonylureas, which are excreted primarily in the urine.
American ginseng or a each day for eight weeks, at which point they switched treatments. The diabetic patients' blood sugar levels dropped about 9% more when they took ginseng compared with when they took the placebo; glycosylated hemoglobin levels between the two groups differed by 4%, with the ginseng group being lower. The blood glucose level was normal in one breastfed infant whose mothers was taking oral glyburide 5 mg daily. Q7. Can Glyburide and Metformin hydrochloride tablets cause side effects?
The normal values listed here-called a reference range-are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what's normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab. Remove the band from your arm when enough blood is collected. Gastrointestinal Reactions: Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure; Glyburide Tablets should be discontinued if this occurs.
Although it is not known whether glyburide is excreted in human milk, some sulfonylurea drugs are known to be excreted in human milk. Studies in lactating rats show that metformin is excreted into milk and reaches levels comparable to those in plasma. Similar studies have not been conducted in nursing mothers. Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue Glyburide and Metformin hydrochloride, taking into account the importance of the drug to the mother. If Glyburide and Metformin hydrochloride is discontinued, and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.
Overdose of metformin hydrochloride has occurred, including ingestion of amounts greater than 50 grams. Hypoglycemia was reported in approximately 10% of cases, but no causal association with metformin hydrochloride has been established. Lactic acidosis has been reported in approximately 32% of metformin overdose cases see WARNINGS. You may get a small at the site. You can lower the chance of bruising by keeping pressure on the site for several minutes. Complete removal of the pancreas pancreatectomy causes a C-peptide level so low it can't be measured. The blood glucose level will be high, and insulin will be needed in order for the person to survive. Do not share it with other people. Allow octreotide to come to room temperature before using. Do not warm or thaw octreotide with hot water or by placing in the microwave. Some patients who are initially responsive to oral hypoglycemic drugs, including glyburide, may become unresponsive or poorly responsive over time. Alternatively, Glyburide Tablets may be effective in some patients who have become unresponsive to one or more other sulfonylurea drugs. Elderly patients are particularly susceptible to hypoglycemic action of glucose-lowering drugs. Hypoglycemia may be difficult to recognize in the elderly see PRECAUTIONS. The initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. Consult your doctor or pharmacist about the use of reliable while using this medication. Single dose studies with Glynase PresTab Tablets in normal subjects demonstrate significant absorption of glyburide within one hour, peak drug levels at about two to three hours, and low but detectable levels at twenty-four hours. When colesevelam is coadministered with glyburide, maximum plasma concentration and total exposure to glyburide is reduced. Therefore, Diaβeta should be administered at least 4 hours prior to colesevelam. Alka-Seltzer effervescent tablets may reduce the number of clot-forming cells platelets in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools. Concomitant administration of bosentan. WARNING: A small number of people who have taken metformin hydrochloride have developed a serious condition called lactic acidosis. Properly functioning kidneys are needed to help prevent lactic acidosis. Most people with kidney problems should not take Glucovance. See Question Nos. 9-13. The risk of hypoglycemia is increased when caloric intake is deficient, when strenuous exercise is not compensated by caloric supplementation, or during concomitant use with other glucose-lowering agents or ethanol. Renal or hepatic insufficiency may cause elevated drug levels of both Glyburide and Metformin hydrochloride, and the hepatic insufficiency may also diminish gluconeogenic capacity, both of which increase the risk of hypoglycemic reactions. Elderly, debilitated, or malnourished patients and those with adrenal or pituitary insufficiency or alcohol intoxication are particularly susceptible to hypoglycemic effects. Hypoglycemia may be difficult to recognize in the elderly and people who are taking beta-adrenergic blocking drugs.
In elderly patients, debilitated or malnourished patients, and patients with impaired renal or hepatic function, the initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. See Section. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Do not remove the medicine from the package until you are ready to take it. Make sure that your hands are dry when you open Alka-Seltzer effervescent tablets. Prolonged severe hypoglycemia 4 to 10 days has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported more frequently with the use of agents with prolonged half-lives. If Glynase PresTab is used during pregnancy, it should be discontinued at least two weeks before the expected delivery date. The ADA steers people away from herbal remedies altogether. During a C-peptide stimulation test, a blood sample is taken to measure C-peptide. Then a shot of a hormone to increase blood sugar glucagon is given into a vein in the arm. Another blood sample is taken. Safety and efficacy have not been established. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Anne Daly, MS, RD, a diabetes educator with the organization. "And we can't be sure that all are equivalent. bactrim
Single-dose studies with glyburide tablets in normal subjects showed significant absorption of glyburide within 1 hour and detectable levels at 24 hours. AUC of the glyburide component. Remind your doctor that you are taking Glucovance when any new drug is prescribed or a change is made in how you take a drug already prescribed. Glucovance may interfere with the way some drugs work and some drugs may interfere with the action of Glucovance. This can happen if you are sick with a fever, vomiting, or diarrhea. Keep out of reach of children. Q14. Can I take Glyburide and Metformin hydrochloride tablets withother medications? enone.info albendazole
GLUCOVANCE and bosentan is contraindicated. An overdose of glyburide may induce a mild to severe hypoglycemic state and a metformin overdose over 85 grams may cause lactic acidosis. Properly functioning kidneys are needed to help prevent lactic acidosis. Most people with kidney problems should not take Glyburide and Metformin Hydrochloride Tablets See Question Nos. Everett JA. Use of oral antidiabetic agents during breastfeeding. J Hum Lact. If you have any questions about Alka-Seltzer effervescent tablets, please talk with your doctor, pharmacist, or other health care provider. Metformin: Steady-state concentration is reached in 24-48 hours. GLUCOVANCE with meals can help reduce these side effects. AIDS can cause lactic acidosis. If you are on any of these and have any symptoms of lactic acidosis, get medical help immediately. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody or black stools; confusion; diarrhea; dizziness; drowsiness; hearing loss; ringing in the ears; severe stomach pain; unusual bruising; vomiting. Cholestatic, hepatocellular, and mixed hepatocellular liver injury have been reported with postmarketing use of metformin. Assess renal function prior to initiation of Glyburide and Metformin hydrochloride and periodically thereafter.
Before initiating Glyburide and Metformin hydrochloride, obtain an estimated glomerular filtration rate eGFR. Glyburide Tablets USP, 5 mg are light-green colored, round, bi-convex, compressed tablets engraved with N horizontal bisect 344 on one side and 5 on the other side. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. The hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents. When such drugs are administered to a patient receiving Glyburide and Metformin hydrochloride, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving Glyburide and Metformin hydrochloride, the patient should be observed closely for loss of blood glucose control. Check with your doctor if you have questions. He recommends starting with 200 micrograms of chromium three times per day, and then reducing the dose to twice per day if blood sugar levels improve. GLUCOVANCE should be administered at least 4 hours prior to colesevelam. Due to a lack of dose proportionality, increased doses of metformin may not result in greater bioavailability. Treatment of patients with glucose-6-phosphate dehydrogenase G6PD deficiency with sulfonylurea agents can lead to hemolytic anemia. Because Glucovance belongs to the class of sulfonylurea agents, caution should be used in patients with G6PD deficiency and a non-sulfonylurea alternative should be considered. In postmarketing reports, hemolytic anemia has also been reported in patients who did not have known G6PD deficiency. Q13. What does my doctor need to know to decrease my risk of lactic acidosis? Do not take Glucovance if you are taking bosentan used for pulmonary arterial hypertension PAH which is high blood pressure in the vessels of the lungs. They tend to be dose-related and may disappear when dosage is reduced. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated 50% glucose solution. The risk of lactic acidosis may, therefore, be significantly decreased by regular monitoring of renal function in patients taking metformin and by use of the minimum effective dose of metformin. In particular, treatment of the elderly should be accompanied by careful monitoring of renal function. aldactone
Surgery and other procedures - Withholding of food and fluid during surgical or other procedures may increase the risk for volume depletion, hypotension, and renal impairment. Glyburide and Metformin hydrochloride should be temporarily discontinued while patients have restricted food and fluid intake. In order to avoid hypoglycemia, the starting dose of glyburide and metformin hydrochloride tablets should not exceed the daily doses of glyburide or metformin already being taken. In elderly patients, debilitated or malnourished patients, and patients with impaired renal or hepatic function, the initial and maintenance dosing should be conservative to avoid hypoglycemic reactions see section. Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin. Metformin is known to be substantially excreted by the kidney, and the risk of metformin accumulation and lactic acidosis increases with the degree of impairment of renal function. Thus, patients with serum creatinine levels above the upper limit of normal for their age should not receive Glucovance. In patients with advanced age, Glucovance should be carefully titrated to establish the minimum dose for adequate glycemic effect, because aging is associated with reduced renal function. WARNING: A small number of people who have taken metformin hydrochloride have developed a serious condition called lactic acidosis. Single-dose studies with glyburide tablets in normal subjects demonstrate significant absorption of glyburide within one hour, peak drug levels at about four hours, and low but detectable levels at twenty-four hours. Mean serum levels of glyburide, as reflected by areas under the serum concentration-time curve, increase in proportion to corresponding increases in dose. Bioequivalence has not been established between glyburide and metformin hydrochloride tablets and single ingredient glyburide products. Q16. How do I take Glucovance? See USP Controlled Room Temperature. Contact your doctor or health care provider right away if any of these apply to you. Other medications can affect the removal of linagliptin from your body, which may affect how linagliptin works. People who have a condition known as glucose-6-phosphate dehydrogenase G6PD deficiency and who take Glyburide and Metformin Hydrochloride Tablets may develop hemolytic anemia fast breakdown of red blood cells. G6PD deficiency usually runs in families. Tell your doctor if you or any members of your family have been diagnosed with G6PD deficiency before you start taking Glyburide and Metformin hydrochloride tablets. The safety and efficacy of Glyburide and Metformin hydrochloride were evaluated in an active-controlled, double-blind, 26-week randomized trial involving a total of 167 pediatric patients ranging from 9-16 years of age with type 2 diabetes. Glyburide and Metformin hydrochloride was not shown statistically to be superior to either metformin or glyburide with respect to reducing HbA 1c from baseline see . No unexpected safety findings were associated with Glyburide and Metformin hydrochloride in this trial. Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs. There are no adequate and well-controlled studies in pregnant women with glyburide and metformin or its individual components. No animal studies have been conducted with the combined products in glyburide and metformin. The following data are based on findings in studies performed with the individual products. coversyl price mercury drug store
Glyburide: 10 hours serum. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Single-dose studies with Diaβeta in normal subjects demonstrate significant absorption within one hour, peak drug levels at about four hours, and low but detectable levels at twenty-four hours. Mean serum levels of glyburide, as reflected by areas under the serum concentration-time curve, increase in proportion to corresponding increases in dose. Multiple-dose studies with Diaβeta in diabetic patients demonstrate drug level concentration-time curves similar to single-dose studies, indicating no build-up of drug in tissue depots. The decrease of glyburide in the serum of normal healthy individuals is biphasic, the terminal half-life being about 10 hours. In single-dose studies in fasting normal subjects, the degree and duration of blood glucose lowering is proportional to the dose administered and to the area under the drug level concentration-time curve. The blood glucose lowering effect persists for 24 hours following single morning doses in non-fasting diabetic patients. Under conditions of repeated administration in diabetic patients, however, there is no reliable correlation between blood drug levels and levels. A one-year study of diabetic patients treated with Diaβeta showed no reliable correlation between administered dose and serum drug level. Your risk of developing lactic acidosis from taking Glucovance is very low as long as your kidneys and liver are healthy. However, some factors can increase your risk because they can affect kidney and liver function. You should discuss your risk with your doctor. Combinations containing any of the following medications, depending on the amount present, may also interact with this medication. Patients receiving Glyburide and Metformin hydrochloride in combination with a thiazolidinedione may be at risk for hypoglycemia. Symptoms may include agitation; fever; hearing loss; lethargy; lightheadedness, especially upon standing; nausea; rapid breathing; rapid or irregular heartbeat; ringing in the ears; seizures; shortness of breath; stomach pain; vomiting. Glucovance do not necessarily indicate impending lactic acidosis and may be explainable by other mechanisms, such as poorly controlled diabetes or obesity, vigorous physical activity, or technical problems in sample handling. Sweet Eze, a mixture of herbs and minerals sold for diabetes. The supplement seemed to work wonders for the self-described "old hippie.
There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Glynase PresTab or any other anti-diabetic drug. Glyburide and Metformin hydrochloride tablets combines Glyburide and Metformin hydrochloride, 2 antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes. Glyburide is mainly metabolized by CYP 2C9 and to a lesser extent by CYP 3A4. There is a potential for drug-drug interaction when glyburide is coadministered with inducers or inhibitors of CYP 2C9, which should be taken into account when considering concomitant therapy. When such drugs are administered to a patient receiving Diaβeta, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving Diaβeta, the patient should be observed closely for hypoglycemia. Hepatic impairment - Patients with hepatic impairment have developed cases of metformin-associated lactic acidosis. This may be due to impaired lactate clearance resulting in higher lactate blood levels. Therefore, avoid use of Glyburide and Metformin hydrochloride in patients with clinical or laboratory evidence of hepatic disease. Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. It may harm an unborn baby. If you become or think you may be pregnant, tell your doctor right away. Daily doses of more than 12 mg are not recommended. Glucovance is capable of producing hypoglycemia or hypoglycemic symptoms, therefore, proper patient selection, dosing, and instructions are important to avoid potential hypoglycemic episodes. The risk of hypoglycemia is increased when caloric intake is deficient, when strenuous exercise is not compensated by caloric supplementation, or during concomitant use with other glucose-lowering agents or ethanol. Renal or hepatic insufficiency may cause elevated drug levels of both glyburide and metformin hydrochloride, and the hepatic insufficiency may also diminish gluconeogenic capacity, both of which increase the risk of hypoglycemic reactions. Elderly, debilitated, or malnourished patients and those with adrenal or pituitary insufficiency or alcohol intoxication are particularly susceptible to hypoglycemic effects. Hypoglycemia may be difficult to recognize in the elderly and people who are taking beta-adrenergic blocking drugs. Your doctor will tell you how many Glyburide and Metformin Tablets to take and how often. This should also be printed on the label of your prescription. You will probably be started on a low dose of glyburide and metformin and your dosage will be increased gradually until your blood sugar is controlled. Lab tests, including blood sugar levels, growth hormone levels, and thyroid function, may be performed while you use octreotide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. In order to avoid hypoglycemia, the starting dose of Glyburide and Metformin hydrochloride should not exceed the daily doses of glyburide or metformin already being taken. USP with 500 mg metformin hydrochloride, USP and 5 mg glyburide, USP with 500 mg metformin hydrochloride, USP. In addition, each tablet contains the following inactive ingredients: Sodium Starch Glycolate, Povidone, Colloidal Silicon Dioxide, Magnesium Stearate. The tablets are film coated, which provides color differentiation. With concomitant glyburide and metformin therapy, the desired control of blood glucose may be obtained by adjusting the dose of each drug. However, attempts should be made to identify the optimal dose of each drug needed to achieve this goal. With concomitant glyburide and metformin therapy, the risk of hypoglycemia associated with sulfonylurea therapy continues and may be increased. Appropriate precautions should be taken see Section. The symptoms happen in the moment. The soreness you sometimes feel in your muscles a day or two after an intense isn't from lactic acidosis. It's your muscles recovering from the workout you gave them. accutane in canada price
Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. If any of these effects persist or worsen, tell your doctor or promptly. If symptoms return later after taking the same dose for several days or weeks tell your doctor right away. Short-term administration of Diaβeta may be sufficient during periods of transient loss of control in patients usually controlled well on diet. Glynase PresTab Tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Glyburide and metformin combination should be taken with food to reduce gastrointestinal symptoms. The blood glucose lowering effect persists for 24 hours following single morning doses in nonfasting diabetic patients. Under conditions of repeated administration in diabetic patients, however, there is no reliable correlation between blood drug levels and fasting blood glucose levels. A one year study of diabetic patients treated with glyburide showed no reliable correlation between administered dose and serum drug level. Weight gain was seen with the addition of rosiglitazone to glyburide and metformin, similar to that reported for thiazolidinedione therapy alone. Liver function abnormalities, including isolated transaminase elevations, have been reported. Prolonged severe hypoglycemia 4-10 days has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported more frequently with the use of agents with prolonged half-lives. It is not recommended that Glucovance be used during pregnancy. However, if it is used, Glucovance should be discontinued at least 2 weeks before the expected delivery date. When this happens, sugar glucose builds up in the blood. This can lead to serious medical problems, including kidney damage, amputations, and blindness. Diabetes is also closely linked to heart disease. The main goal of treating diabetes is to lower your blood sugar to a normal level. generic clamoxin order mastercard usa
Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation during treatment with Glyburide and Metformin Tablets; when it occurs, it is fatal in approximately 50% of cases. Lactic acidosis may also occur in association with a number of pathophysiologic conditions, including diabetes mellitus, and whenever there is significant tissue hypoperfusion and hypoxemia. It may increase the risk of death from heart disease. Talk with your doctor about the benefits and risks of this or other therapies to treat your condition. The serum concentration of glyburide in normal subjects decreased with a half-life of about four hours. An increased risk of liver enzyme elevations was observed in patients receiving glyburide concomitantly with bosentan. Therefore concomitant administration of Glyburide Tablets and bosentan is contraindicated. The effectiveness of any oral hypoglycemic drug, including Diaβeta, in lowering blood glucose to a desired level decreases in many patients over a period of time, which may be due to progression of the severity of the or to diminished responsiveness to the drug. Excessive Alcohol intake - Alcohol is known to potentiate the effect of metformin on lactate metabolism. Patients, therefore, should be warned against excessive alcohol intake, acute or chronic, while receiving Glyburide and Metformin hydrochloride. In a single-dose interaction study in NIDDM subjects, decreases in glyburide AUC and C max were observed, but were highly variable. The single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effects, makes the clinical significance of this interaction uncertain. Coadministration of glyburide and metformin did not result in any changes in either metformin pharmacokinetics or pharmacodynamics. Metformin, one of the medicine in Glyburide and Metformin hydrochloride tbalets can cause a rare but serious condition calles lactic acidosis a build up of an acid in the blood that can cause death. Lacticacidosis is a medical emergency and muct be treated in the hospital. No animal studies have been conducted with the combined products in Glyburide and Metformin hydrochloride. The following data are based on findings in studies performed with the individual products. HbA in patients randomized to glyburide or metformin therapy. Type I diabetes mellitus.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. During this conversion period when both insulin and Glyburide Tablets are being used, hypoglycemia may occur. During insulin withdrawal, patients should test their urine for glucose and acetone at least three times daily and report results to their physician. The appearance of persistent acetonuria with glycosuria indicates that the patient is a Type I diabetic who requires insulin therapy. Properly functioning kidneys are needed to help prevent lactic acidosis. Check with your health care provider before you start, stop, or change the dose of any medicine. Glucovance experienced hypoglycemic symptoms. GLUCOVANCE and its side effects. canada propecia generico
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Before using, check this product visually for particles or discoloration. If either is present, not use the liquid. Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. More insulin is made in people and can cause high levels of C-peptide. Recent information strongly suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities. Most experts recommend that insulin be used during pregnancy to maintain blood glucose as close to normal as possible. Because animal reproduction studies are not always predictive of human response, Glyburide and Metformin hydrochloride should not be used during pregnancy unless clearly needed. See below. rosuvastatin
Octreotide is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using octreotide at home, a health care provider will teach you how to use it. Be sure you understand how to use octreotide. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. What are the most common side effects of glyburide and metformin? Do not take glyburide and metformin if you are taking bosentan used for pulmonary arterial hypertension PAH which is high blood pressure in the vessels of the lungs. Educate patients and their families about the symptoms of lactic acidosis and if these symptoms occur instruct them to discontinue Glyburide and Metformin hydrochloride and report these symptoms to their healthcare provider.
Treatment with Glyburide and Metformin hydrochloride resulted in significantly greater reduction in HbA 1c and postprandial plasma glucose PPG compared to glyburide, metformin, or placebo. Also, Glyburide and Metformin hydrochloride therapy resulted in greater reduction in FPG compared to glyburide, metformin, or placebo, but the differences from Glyburide and Metformin did not reach statistical significance. Octreotide may cause dizziness, drowsiness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use octreotide with caution. Once-a-day therapy is usually satisfactory, based upon usual meal patterns and a 10 hour half-life of Diaβeta. Some patients, particularly those receiving more than 10 mg daily, may have a more satisfactory response with twice-a-day dosage.
These situations can lead to severe dehydration, and it may be necessary to stop taking Glucovance temporarily. See Section for patients at increased risk. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment.